CO2 extract Rosemary

Rosmarinus officinalis

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    Rosemary Antioxidant extract

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    6.58 €


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    Rosemary CO2 Extract

    Raw material

    Rosmarinus officinalis - Leaves, dried, from organic farming

    Extraction method

    The Rosmary extract is produced by supercritical fluid extraction with natural carbon dioxide and a small amount of alcohol as entrainer, no inorganic salts, no heavy metals, no reproducible microorganisms [1]. The CO2-extract is standardised with certified organic sunflower oil.


    12 - 16 % Antioxidative reference compounds: phenolic diterpenes carnosic acid and carnosol calc. as carnosic acid with > 10 % carnosic acid; total volatile flavour compounds < 4 %, water < 1 %, ethanol < 2 %, sunflower oil, cuticular waxes.

    Traditional Use

    Rosemary (Rosmarinus officinalis) has been used in Europe since ancient times as tonic, stimulant, and carminative to treat dyspepsia, headaches and nervous tension. The ancient Greeks used it to strengthen memory function and concentration. In India, rosemary leaves are used in Ayurvedic Medicine for treatment of flatulent dyspepsia associated with psychogenic tension and migraine headaches.

    Cosmetic and Food:

    Rosemary CO2-Antioxidant has antioxidative, antimicrobial and anti-inflammatory properties. It retards oxidation of fatty oils, carotenoids and essential oils and it is used in food industry (dressings, sausages, snacks,etc.), in food supplements and in cosmetics. Dosage 0,05 - 0,1 % in case of saturated fats, 0,2 - 0,4 % in case of polyunsaturated oils. EU declaration, if used in food and supplements: Natural Antioxidant Rosemary Extract or Natural Antioxidant E 392.

    A screening for antimicrobial activity of Rosemary CO2-Antioxidant by disk diffusion assays and agar dilution tests demonstrated a broad spectrum of activity against 28 germs, different Staphylococcus and Streptococcus, Corynebacterium and Pseudomonas species as well as against Bacillus subtilis, Micrococcus luteus, Propionibacterium acnes and Candida species in concentrations as low as 0,1 % or less. The efficacy against gram positive bacteria was superior to gram negative bacteria and fungi with a 5 to 10 fold higher minimal inhibitory concentration [2].

    Rosemary CO2-Antioxidant has also anti-aging properties. Topical application inhibits the oxidation of polyunsaturated fatty acids in membranes and the non-enzymatic glycosylation of proteins.

    Also anti-inflammatory, cytostatic and cytotoxic activities of Rosemary extract when applied topically are described [3-4].

    Food Supplements:

    A significant number of in vitro and in vivo studies provide evidence that Rosemary extract and its bioactive Diterpene Phenols (DTPs) have anticancer [5], antidiabetic [6], antioxidant [6-7], antiulcerogenic [8] and hepatoprotective [9-10] effects.

    In vitro and in vivo trials demonstrate also improvement of cognitive deficits [11]. Diterpene Phenols (DTPs) of Rosemary have shown in vitro and in vivo to inhibit neuronal cell death. The multifunctional nature of the compounds from the general antioxidant-mediated neuronal protection to other specific mechanisms including brain inflammation and amyloid beta (Aß) formation, polymerisation, and pathologies is discussed. The therapeutic potential of these compounds for Alzheimer´s disease (AD) should be considered [12].

    (Statements summarise literature evidence and have informative character. They might be derived from in vitro or animal tests and thus not be substantiated for humans. Statements have not been evaluated by competent authorities and do not refer to finished products. The marketer of any finished product containing any extract as ingredient is responsible for assuring that the claims made for his product are lawful and comply with all applicable laws and regulations of the country in which the product is to be sold.)


    [1] Liu Xiong; Han Jianquan; Hu Biqing : Extracting and refining pomelo peel oil with supercritical carbon dioxide fluid. : Food and Machinery, (2003), No. 4, 13-14, 5 ref.; ISSN: 1003-5788

    [2] P. Manninen, E. Häivälä, S. Sarimo, H. Kallio : Distribution of microbes in supercritical CO2 extraction of sea buchthorn (Hippophae rhamnoides) oils : Zeitschrift für Lebensmitteluntersuchung und -Forschung / Springerverlag (1997) 204: 202-205

    [3] Weckesser S : Testung der antibakteriellen und antimykotischen Aktivität ausgewählter Pflanzenextrakte gegenüber dermatologisch relevanten Keimen : Dissertation, Albert-Ludwigs-Universität Freiburg (2006).

    [4] Jocher A et al : : Poster, Phytotherapy Congress Berlin, Sept. 28-30 (2006)

    [5] Cattaneo L, Cicconi R, Mignogna G, Giorgi A, Mattei M, Graziani G, Ferracane R, Grosso A, Aducci P, Schininà ME, Marra M : Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells :

    [6] Moore J, Yousef M, Tsiani E : Review Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols : Nutrients. 2016 Nov 17;8(11). pii: E731.

    [7] Moore J, Yousef M, Tsiani E : Review Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols : Nutrients. 2016 Nov 17;8(11). pii: E731.

    [8] Bakirel T, Bakirel U, Keles OU, Ulgen SG and Yardibi H : In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits : Ethnopharmacology, vol. 116, no. 1, pp. 64-73, 2008.

    [9] Laura PF, Garzon MT, Vicente M : Relationship between the antioxidant capacity and effect of rosemary (Rosmarinus officinalis L.) polyphenols on membrane phospholipid order : Journal of Agricultural and Food Chemistry, vol. 58, no. 1, pp. 161-171, 2010.

    [10] Correa Dias P, Foglio MA, Possenti A, De Carvalho JE : Antiulcerogenic activity of crude hydroalcoholic extract of Rosmarinus officinalis L : Journal of Ethnopharmacology, vol. 69, no. 1, pp. 57-62, 2000.

    [11] Abdel-Wahhab KGED, El-Shamy KA, El-Beih NAEZ, Morcy FA, and Mannaa FAE : Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats : Comunicata Scientiae, vol. 2, no. 1, pp. 9-17, 2011.

    [12] Sotelo-Felix JI, Martinez-Fong D, and De la Torre PM : Protective effect of carnosol on CCl4-induced acute liver damage in rats : European Journal of Gastroenterology & Hepatology, vol. 14, no. 9, pp. 1001-1006, 2002.

    [13] Kennedy DO and Scholey AB : The psychopharmacology of European herbs with cognition-enhancing properties : Current Pharmaceutical Design, vol. 12, no. 35, pp. 4613-4623, 2006

    [14] Habtemariam S : The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer´s Disease : Evid Based Complement Alternat Med. 2016;2016

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